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PICK: Memphis at #17 Tulane (-13) 
The Green Wave are 9-2 both straight up and ATS this season. Meanwhile, Memphis has won five of its last six games.
PICK: Lions (-9.5) host Bears
The early money has arrived on Chicago, moving the spread down from 10.5 points.
PICK: Giants at Cowboys (-3.5)
Drew Lock will start at quarterback for New York, while Cooper Rush remains the Dallas starter in place of the injured Dak Prescott.
PICK: #5 Indiana at #2 Ohio St. (-10.5)
The undefeated Hoosiers have a chance to silence critics with this high-profile showdown at the Horseshoe. Curt Cignetti and the Hoosiers are 8-2 ATS this season can shake up the playoff mix with a strong performance.
PICK: #4 Penn St. (-4.5) at Minnesota
The Gophers have won four of their last five games but did lose last weekend at Rutgers. Meanwhile, the Nittany Lions are 3-3 as a double-digit favorite this season.
PICK: USC (-4.5) at UCLA
This rivalry game has postseason implications with the Trojans one win away from bowl-eligibility. Plus, the Bruins are two wins away with two remaining games.
PICK: Chiefs (-11) at Panthers
Kansas City suffered its first loss and now faces arguably the league's worst team. However, Carolina has won back-to-back games and is coming off a bye.
PICK: 49ers at Packers (-5.5)
San Francisco faces this virtual must-win game without quarterback Brock Purdy and defensive standout Joey Bosa. When the injury news surfaced, the point spread moved from two points to 5.5 points.
TNF PICK: Steelers (-3.5) at Browns
Pittsburgh is 8-2 and eyeing a division title but has to travel on a short week against a division rival. However, the Steelers are undefeated with Russell Wilson at quarterback and are 8-2 ATS overall this season.
PICK: Magic at Lakers (-4.5)
The Lakers have won six straight games and sit in third place in the Western Conference. Plus, Dalton Knecht is coming off a 37-point performance and his points prop is only 12.5.