PICK: Jaguars at Bills (-5.5) 🎥
Buffalo is 2-0 to start the season and hosts a winless Jacksonville squad. However, six 0-2 teams won outright on Sunday.
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PICK: Commanders at Bengals (-7.5) 🎥
Cincinnati is winless and favored by more than a touchdown. Washington would likely be winless, if the Giants had a healthy kicker available for last week's game.
PICK: Chiefs (-3) at Falcons 🎥
The two-time defending champions hit the road for the first time this season. Meanwhile, Atlanta is coming off a thrilling comeback win on Monday Night Football.
PICK: #11 USC (-4.5) at Michigan 🎥
The Trojans open Big Ten play at the Big House against a Wolverines team that so far has performed well below expectations. But is this point spread too much of an adjustment?
ANALYSIS: Why to bet Steelers now 🎥
Chargers quarterback Justin Herbert is battling an ankle injury and may not play on Sunday against Pittsburgh. With this uncertainty, what is the best approach to betting the game?
PICK: #6 Tenn. (-7) at #15 Oklahoma 🎥
Both teams are undefeated but the Vols have looked far more impressive through three games. However, the Sooners are getting some key players back from injury ahead of the weekend's marquee matchup.
PICK: #12 Utah (PK) at #14 Oklahoma St. 🎥
With the status of Utes QB Cam Rising creating massive uncertainty all week, this point spread has seen wild fluctuation. Both teams are 3-0 heading into this Big 12 opener.
PICK: Ravens (-1) at Cowboys 🎥
Both contenders are coming off disappointing losses and now look to get back on track. Baltimore is 0-2 but a slight road favorite.
PICK: Stanford at Syracuse (-8.5) 🎥
The Orange are undefeated and Ohio State transfer QB Kyle McCord has put up impressive numbers. Plus, Stanford is 2-0 ATS so far this season.
PICK: #24 Illinois at #22 Nebraska (-8) 🎥
For the first time in more than a decade, there is a ranked matchup in Lincoln. Nebraska hosts Illinois in the Big Ten opener for both 3-0 teams.