Patrick Mahomes and two-time defending Kansas City host Cincinnati in a marquee matchup. Under Zac Taylor, the Bengals are only 1-10 in the first two weeks of the regular season.
In a matchup of young franchise quarterbacks on Sunday Night Football, CJ Stroud and Houston are a solid home favorite over Caleb Williams and Chicago.
Saturday's lone ranked matchup features the surprisingly undefeated Eagles headed to SEC country. The Tigers have yet to allow a single point in their first two games but BC presents a much tougher test.
Kalen DeBoer faces his first true test as Nick Saban's replacement, as the Crimson Tide head to Camp Randall. The Badgers are 2-0 but both wins have been underwhelming.
The Ducks are undefeated but it's been a bit bumpy, only outscoring their first two opponents by a combined 13 points. And now they face their rival on the road.
The Fighting Irish are coming off a huge upset that may have derailed their playoff chances. They try to get back on track as a road favorite at Purdue.
The weekend's top college football game arrives on a Friday in the Little Apple. Kansas State hosts a puzzling Arizona team that has managed a 2-0 start.
Dallas has been eliminated from the playoffs and has lost seven straight games, failing to cover all seven. Seattle is chasing Las Vegas for the #4 seed with the playoffs around the corner.
Connecticut is battling for the #2 overall seed with just four games remaining in the regular season. Plus, Phoenix star Kahleah Copper is listed as questionable with a back injury.