Rookie quarterback Caleb Williams and Chicago have won consecutive games and now travel to London. Meanwhile, the Jags last week became the last team to notch their first win.
Rookie Jayden Daniels has created serious buzz, leading Washington to a 4-1 record. However, a dose of reality could be coming when the Commanders visit Lamar Jackson and Baltimore.
In a rematch of their memorable game last year, Detroit is coming off a bye and looking to improve to 4-1. Meanwhile, Dallas is headed into its bye after its second straight primetime game.
Despite losing for the third time in four weeks and having a losing record, the San Francisco 49ers remain the NFC betting favorites with +420 odds at FanDuel.
After another strong statistical game and fourth straight win, rookie quarterback Jayden Daniels is now the fifth betting favorite for the NFL MVP with +1000 odds at DraftKings.
Both teams are coming off disappointing losses ahead of Thursday Night Football. San Francisco has blown two 10-point leads in the fourth quarter against division opponents.
San Francisco snapped its two-game skid and remains the NFC betting favorites with a 2-2 record. This point spread has bounced back and forth between 7 and 7.5.