Buffalo has won seven straight games, including a 6-1 ATS mark during this run. Now, after clinching the division on national television, they fly across the country and face a frisky Rams squad.
Rookie quarterback Bo Nix and Denver look to continue their surprising season. Jameis Winston and Cleveland are coming off a home upset over the Steelers.
In perhaps the season's most memorable play, Josh Allen recorded a unique receiving touchdown in snow conditions on national tv, as the quarterback became the odds-on NFL MVP favorite with -230 odds at FanDuel.
San Francisco is still mathematically alive for the playoffs and will get Brock Purdy back from injury. Meanwhile, Josh Allen is the MVP favorite and Buffalo is pursuing the AFC's top seed.